Are you thirsty? Do you like beer? No. Really. Do you like real beer, with hops and color and flavor and all that other goodness that you won't find in Asahi or Budweiser?
Popeye is a great place to really taste some good Japanese beer, and it's convenient to Akihabara via JR train. If you're going to the Edo Tokyo Museum or the Sumo Wrestling Museum, you'll be in Ryogoku, so be sure to swing by. For those who might visit multiple times, be sure to get a membership card (300 yen, I believe) - you can earn discounts and they send occasional coupons.
What about English? They have an English website, and their menu is half-English and half Japanese, so you can read and then point. Some of the waiters can speak English decently but probably won't carry on a conversation with you. I talked for a while with an older Japanese guy on my first visit who was mute. How did we talk? He knew enough vocabulary and would write words on paper. Pretty fun!
The website is located here. Be sure to print out the coupon before you go (a new one every month, usually). It usually gives you a good discount (half off) a certain beer. And a link to Google Maps is here so you can navigate in English (Popeye's English map is fairly basic).